Medications That Cause Weight Gain

Steph Wagner MS, RDN

January 14, 2025

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What you need to know

Yes, the rumors are true—some medications can cause weight gain, and it’s not just an excuse. If you’ve ever wondered how certain medications might affect your weight or which ones are the culprits, you’re in the right place.

As a Registered Dietitian specializing in Obesity care, this is a topic I want to cover. The connection between prescription medications and weight gain—a topic that can be especially frustrating for those managing their weight after bariatric surgery. 

How Do Medications Cause Weight Gain?

Not all medications cause weight gain the same way. Some directly impact your body, while others create side effects that make weight management more difficult. Here’s how it works:

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Medications Linked to Weight Gain

While this is not an exhaustive list, here are some common culprits, especially for bariatric patients. An even better resource can be found from the Obesity Action Coalition written by Ted Kyle, RPh, MBA, and Bonnie Kuehl, PhD.

Diabetes Medications

Insulin (Humalog, Novolog): While effective at managing blood sugar, insulin can promote weight gain.

Alternatives: Your doctor may consider other medications that control blood sugar without causing weight changes.

Antidepressants

SSRIs (Zoloft, Paxil, Celexa): These medications are often linked to weight gain.

Alternatives: Some options, like Bupropion, can help manage symptoms while also reducing appetite.

Antiseizure Medications

Gabapentin: Commonly prescribed for nerve pain and seizures, it’s also associated with weight gain.

Steroids

Prednisone: A well-known troublemaker, steroids can lead to increased appetite, fluid retention, and weight gain.

Antihistamines

Benadryl: Even some over-the-counter allergy medications can contribute to weight gain by increasing appetite or causing fatigue.

What You Can Do

If you suspect that your medication might be affecting your weight, it’s important to take a proactive approach. Start by asking questions—talk to your healthcare provider about any potential weight-related side effects before beginning a new prescription.

Keep an eye on changes by maintaining a journal of your weight and appetite, and share any significant observations with your doctor. In some cases, weight-neutral or weight-loss-promoting alternatives may be available, so explore these options with your provider.

Finally, while medications can play a role in weight changes, focusing on a balanced diet and staying active are essential for effective weight management.

Work with an Obesity Medicine Doctor

An Obesity Medicine Doctor can be an invaluable resource in managing weight alongside your health conditions. They can review your medications and recommend alternatives that align with your weight management goals.

To find providers specializing in Obesity care, visit obesitymedicine.org and utilize the Find a Provider feature.

Keep Moving Forward

At Bariatric Food Coach, we’re here to support you every step of the way. Remember, you’re not alone in this journey, and there are always tools, resources, and strategies to help you succeed.

To make things easier, I’ve included a free meal plan as a thank-you for subscribing to my weekly email newsletter. Sign up for free recipes, coaching tips, and more!


You’ve Got This


Weight management is challenging, but knowledge is power. By understanding how medications might be impacting your progress, you’re taking an important step toward your health goals. Keep going—you’re stronger than you think!

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