Medications That Cause Weight Gain
What you need to know
Yes, the rumors are true—some medications can cause weight gain, and it’s not just an excuse. If you’ve ever wondered how certain medications might affect your weight or which ones are the culprits, you’re in the right place.
As a Registered Dietitian specializing in Obesity care, this is a topic I want to cover. The connection between prescription medications and weight gain—a topic that can be especially frustrating for those managing their weight after bariatric surgery.

How Do Medications Cause Weight Gain?
Not all medications cause weight gain the same way. Some directly impact your body, while others create side effects that make weight management more difficult. Here’s how it works:
Increased Appetite: Certain drugs may trigger hunger, making it harder to control portion sizes.
Carbohydrate Storage: Some medications affect how your body absorbs and stores carbohydrates, leading to weight changes.
Slower Metabolism: Medications can alter your metabolic rate, making it more challenging to burn calories.
Reduced Energy Levels: Some medications cause fatigue, making it harder to stay active.
Fluid Retention: While not true weight gain, some medications cause water retention, which can show up on the scale.
Medications Linked to Weight Gain
While this is not an exhaustive list, here are some common culprits, especially for bariatric patients. An even better resource can be found from the Obesity Action Coalition written by Ted Kyle, RPh, MBA, and Bonnie Kuehl, PhD.
Diabetes Medications
Insulin (Humalog, Novolog): While effective at managing blood sugar, insulin can promote weight gain.
Alternatives: Your doctor may consider other medications that control blood sugar without causing weight changes.
Antidepressants
SSRIs (Zoloft, Paxil, Celexa): These medications are often linked to weight gain.
Alternatives: Some options, like Bupropion, can help manage symptoms while also reducing appetite.
Antiseizure Medications
Gabapentin: Commonly prescribed for nerve pain and seizures, it’s also associated with weight gain.
Steroids
Prednisone: A well-known troublemaker, steroids can lead to increased appetite, fluid retention, and weight gain.
Antihistamines
Benadryl: Even some over-the-counter allergy medications can contribute to weight gain by increasing appetite or causing fatigue.
What You Can Do
If you suspect that your medication might be affecting your weight, it’s important to take a proactive approach. Start by asking questions—talk to your healthcare provider about any potential weight-related side effects before beginning a new prescription.
Keep an eye on changes by maintaining a journal of your weight and appetite, and share any significant observations with your doctor. In some cases, weight-neutral or weight-loss-promoting alternatives may be available, so explore these options with your provider.
Finally, while medications can play a role in weight changes, focusing on a balanced diet and staying active are essential for effective weight management.
Work with an Obesity Medicine Doctor
An Obesity Medicine Doctor can be an invaluable resource in managing weight alongside your health conditions. They can review your medications and recommend alternatives that align with your weight management goals.
To find providers specializing in Obesity care, visit obesitymedicine.org and utilize the Find a Provider feature.
Keep Moving Forward
At Bariatric Food Coach, we’re here to support you every step of the way. Remember, you’re not alone in this journey, and there are always tools, resources, and strategies to help you succeed.
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You’ve Got This
Weight management is challenging, but knowledge is power. By understanding how medications might be impacting your progress, you’re taking an important step toward your health goals. Keep going—you’re stronger than you think!
